New Bolton Center comprises the George D. Widener Hospital for Large Animals, featuring one of the world's largest equine surgical facilities, the James M. Moran Jr. Critical Care Center, the Marshak Dairy, the Laboratory of Aquatic Animal Medicine and Pathology and one of Pennsylvania's three Animal Diagnostic Laboratories.

The Widener Hospital sees more than 6,000 patients a year. not including the Field Service, which sees more than 19,000 animals annually at farms, breeders and horse-training facilities and agricultural enterprises in the region.